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Digital Live Now- Payment link & Invoice- Hard Copies Cost - Champions of Health: Spotlight On Leaders Shaping Romania's Healthcare
3S Pharmacological Consultation & Research: Assurance of safety and Uniqueness in limited time
Single Dose Comparative Bioavailability Study of Lisdexamfetamine Dimesylate as Oral Solution Versus Reference Hard Capsules in Healthy Volunteers, Simona Rizea Savu, Simona Nicoleta Duna, Dimitrios Panagiotopoulos and Roxana Colette Sandulovici, Frontiers in Pharmacology doi: 10.3389/fphar.2022.881198, 05 April 2022
Single Dose Study Assessing the Pharmacokinetic and Metabolic Profile of Alverine Citrate in Healthy Volunteers. Frontiers in Pharmacology 11:620451, 2021, doi: 10.3389/fphar.2020.620451
Pharmacokinetics Bridging Study of a 400 Mg Extended Release Formulation of the Novel Fumaric Acid Ester PPC-06 (Tepilamide Fumarate) in Healthy Male Volunteers, Journal of Bioequivalence Studies (ISSN: 2575-551X ), 2020, 6(1):103
The Effect of Food on the Single‐Dose Bioavailability and Tolerability of the Highest Marketed Strength of Duloxetine, Clinical Pharmacology in Drug Development, e-published ahead of print: 02 December 2019 (https://doi.org/10.1002/cpdd.759)
Single Dose Bioequivalence Study of Two Rivaroxaban Tablet Formulations, Administered Orally after Being Crushed and Suspended in Apple Puree, Journal of Bioequivalence & Bioavailability 2019, 11(1): 9-13, (DOI: 10.4172/0975-0851.1000388)
Single Dose Study Assessing the Pharmacokinetic and Metabolic Profile of Alverine Citrate in Healthy Volunteers, by Simona Nicoleta Duna, Simona Rizea-Savu, Roxana Colette Sandulovici, published in Frontiers in Pharmacology, section Drug Metabolism and Transport
Pharmacokinetics Bridging Study of a 400 Mg Extended Release Formulation of the Novel Fumaric Acid Ester PPC-06 (Tepilamide Fumarate) in Healthy Male Volunteers, Journal of Bioequivalence Studies (ISSN: 2575-551X ), 2020, 6(1):103
The Effect of Food on the Single‐Dose Bioavailability and Tolerability of the Highest Marketed Strength of Duloxetine, Clinical Pharmacology in Drug Development, e-published ahead of print: 02 December 2019 (https://doi.org/10.1002/cpdd.759)
Simona Nicoleta Duna, Adrian Ghita, Adelina Ciuciuleaca, Irene Manzanera, David Puibert, Simona Rizea-Savu, Single Dose Bioequivalence Study of Two Rivaroxaban Tablet Formulations, Administered Orally after Being Crushed and Suspended in Apple Puree, Duna et al., J Bioequiv Availab 2019, 11:1, DOI: 10.4172/0975-0851.1000388
Duna SN, Ghita A, Grasser S, Rizea-Savu S, Inovative Use of Medical Infrared Thermography to Evaluate Adhesive Properties of Two Buprenorphine Transdermal Patch Formulations in a Single Dose Adhesion Performance Study, Duna et al., J Bioequiv Availab 2018, 10:5, DOI: 10.4172/0975-0851.1000384
Vuletic, Lucija; Herceg, Marina; Ferderber, Kristina; Tunjic, Iva; Rizea-Savu, Simona, Duna, Simona Nicoleta; Cetina-Cizmek, Biserka; Filipovic-Grcic, Jelena: Single-Dose Pharmacokinetic Properties and Relative Bioavailability of Different Formulations of Posaconazole Oral Suspension in Healthy Volunteers, Clinical Pharmacology in Drug Development, 2018, 00(0) 1-10, 2018, The American College of Clinical Pharmacology, DOI:10.1002/cpdd.636
Sevinsky E, Silvestro L, Neatu A, Roffe C, Rizea-Savu S. Journal of Bioequivalence & Bioavailability - Pharmacokinetic Bioequivalence Study of Two Formulations of Teriflunomide in Healthy Male Volunteers under Fasting Conditions. J Bioequiv Availab 2018, Volume 10(3): 43-47 (2018) – 43, Doi: 10.4172/0975-0851.1000376
Savu SN, Silvestro L, Surmeian M, Remis L, Rasit Y, Savu SR, Mircioiu C.: Evaluation of Clopidogrel Conjugation Metabolism: PK Studies in Man and Mice of Clopidogrel Acyl Glucuronide. Drug Metab Dispos. 2016 Sep;44(9):1490-7. doi: 10.1124/dmd.116.071092. Epub 2016 Jul 11.
Olar R, Calu L, Badea M, Chifiriuc CM, Bleotu C, Velescu B, Stoica O, Ionita G, Stanica N, Silvestro L, Dulea C, Uivarosi V.: Thermal behavior of some biologically active species based on complexes with a triazolopyrimidine pharmacophore. J Therm. Anal. Calorim. doi: 10.1007/s10973-016-5425-7. 2016.
Olar R, Vlaicu ID , Chifiriuc CM, Bleotu C, Stanica N, Scaeteanu GV, Silvestro L, Dulea C, Badea M.: Thermal behavior of new nickel(II) complexes with unsaturated carboxylates and heterocyclic N-donor ligands. J Therm. Anal. Calorim. doi: 10.1007/s10973-016-5445-3. 2016.
Silvestro L, Savu SR: Influence of sample handling conditions on drug partitioning in blood: a major problem in PK studies? Bioanalysis. 2015 Dec;7(23):2973-6. doi: 10.4155/bio.15.209. Epub 2015 Nov 30
Silvestro L, Savu SR. An update on solid phase-supported liquid extraction. Bioanalysis. 2015;7(17):2177-86. doi: 10.4155/bio.15.144. Epub 2015 Sep 17.
Soulele K, Macheras P, Silvestro L, Rizea Savu S, Karalis V. Population pharmacokinetics of fluticasone propionate/salmeterol using two different dry powder inhalers. Eur J Pharm Sci. 2015 Dec 1;80:33-42. doi: 10.1016/j.ejps.2015.08.009. Epub 2015 Aug 19.
Grekas N, Athanassiou K, Papataxiarchou K, Rizea Savu S, Silvestro L.: Pharmacokinetic study for the establishment of bioequivalence of two inhalation treatments containing budesonide plus formoterol. J Pharm Pharmacol. 2014 Aug 11. doi: 10.1111/jphp.12303. [Epub ahead of print] L Silvestro, SN Savu, S Rizea Savu, I Tarcomnicu (2014): Clopidogrel Pharmacokinetic: Review of Early Studies and Novel Experimental Results - Clopidogrel, JP Alesci and A Victorino (Ed.), ISBN: 978-1-62948-336-8, Nova Science Publishers Inc..
Silvestro L, Tarcomnicu I, Dulea C, Attili NR, Ciuca V, Peru D, Rizea Savu S.: Confirmation of diosmetin 3-O-glucuronide as major metabolite of diosmin in humans, using micro-liquid-chromatography-mass spectrometry and ion mobility mass spectrometry. Anal Bioanal Chem. 2013 Oct;405(25):8295-310
Luigi Silvestro, Isabela Tarcomnicu and Simona Rizea Savu (2013): Matrix Effects in Mass Spectrometry Combined with Separation Methods - Comparison HPLC, GC and Discussion on Methods to Control these Effects, Tandem Mass Spectrometry - Molecular Characterization, Dr. Ana Varela Coelho (Ed.), ISBN: 978-953-51-1136-8, InTech, DOI: 10.5772/55982.
Luigi Silvestro, Simona Rizea Savu and Isabela Tarcomnicu (2012). Book Chapter: HPLC-MS/MS of highly polar compounds, published by In Tech, Croatia
Luigi Silvestro, Simona Rizea Savu, Simona Nicoleta Savu, Ariana Tudoroniu and Isabela Tarcomnicu: Development of a Sensitive Method for Simultaneous Determination of Fluticasone and Salmeterol in Plasma Samples by Liquid Chromatography-Tandem Mass Spectrometry, Biomedical Chromatography, 2012 May; 26(5):627-35
Silvestro L, Gheorghe M, Iordachescu A, Ciuca V, Tudoroniu A, Rizea Savu S, Tarcomnicu I.: Development and validation of an HPLC-MS/MS method to quantify clopidogrel acyl glucuronide, clopidogrel acid metabolite, and clopidogrel in plasma samples avoiding analyte back-conversion. Anal. Bioanal. Chem. 2011 Jun 9 [Epub ahead of print]
Silvestro L, Gheorghe MC, Tarcomnicu I, Savu S, Savu SR, Iordachescu A, Dulea C.: Development and validation of an HPLC-MS/MS method to determine clopidogrel in human plasma. Use of incurred samples to test back-conversion. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Nov 15;878(30):3134-42. Epub 2010 Oct 1.
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