Transdermal drug delivery systems (TDDS, TDS) are innovative methods designed to administer medications through the skin, providing a non-invasive alternative to oral and injectable routes. This approach offers several therapeutic advantages, including improved patient compliance and the ability to bypass first-pass metabolism, which can enhance drug bioavailability. Transdermal drug delivery systems, (TDDS, TDS) commonly known as transdermal patches, deliver a controlled amount of medication directly into the bloodstream via the skin.